Aprea Therapeutics, Inc. (NASDAQ : APRE) is a clinical-stage biopharmaceutical company focused on precision oncology through synthetic lethality.
Cancer treatment is at a turning point—and Aprea Therapeutics is at the forefront of this revolution. Investors are starting to notice the massive potential behind this under-the-radar biotech innovator and their game-changing approach to cancer.
The market for cutting-edge oncology treatments is growing, and Aprea Therapeutics is uniquely positioned with its game-changing focus on synthetic lethality therapy.
With a float of less than 5M and few restricted shares, a little bit of investor interest could send this soaring!
Key Level #1: $4.34 (+33.54%)
Key Level #2: $4.99 (+53.54%)
Key Level #3: $6.83 (+110.15%)
Key Level #4: $7.74 (+138.15%)
Potential Support: $2.73
Between Aprea Therapeutics novel macrocyclic ATR inhibitor, ATRN-119, and their next-generation inhibitor of the WEE1 kinase, APR-1051, the company has a long pipeline of treatment options in development to give cancer patients a choice in treatment.
WEE1 is a protein kinase that inhibits premature cell cycle progression. Specifically, WEE1 prevents the premature entry of cells into both the DNA synthetic phase of the cell cycle and the phase in which cells divide after the DNA is duplicated. Through these roles, WEE1 prevents loss of genome stability, particularly in CCNE1-overexpressing cancer cells.
APR-1051 is an orally bioavailable, highly potent, and selective small molecule inhibitor of WEE1. APR-1051 has demonstrated in vivo anti-proliferative activity in multiple cancer cell lines. Importantly, the pharmacodynamic properties of APR-1051 include lower off-target inhibition of three members of the PLK family of kinases (PLK1, PLK2, and PLK3), which may improve its therapeutic value.
ATR Program: ATRN-119
The ataxia telangiectasia and Rad3-related (ATR) kinase is a master regulator of the DNA damage response, with key roles in cell cycle control and DNA repair following replication stress. Aprea Therapeutics has developed ATRN-119, the first macrocyclic ATR inhibitor to enter clinical trials (NCT04905914).
Oren Gilad, Ph. D - Prident and CEO
Oren Gilad, Ph.D., has served as Chief Executive Officer of Aprea Therapeutics since July 2022 and as President and a member of its Board of Directors since May 2022. He previously served as President and CEO of Atrin Pharmaceuticals, Inc., leading its transaction with Aprea Therapeutics. Dr. Gilad brings extensive experience across multiple phases of drug development. During his time at Atrin, he led development from idea through early stage into the clinical stage while securing financing to support pre-clinical and clinical development, regulatory, and intellectual property activities. Before founding Atrin in 2011, Dr. Gilad authored several high-impact scientific publications over a 13-year academic career, including one demonstrating the importance of the ATR pathway in cancer development and treatment. Dr. Gilad earned his doctorate from the University of California at Davis and his B.S. from the Hebrew University, Jerusalem, Israel.
John P. Hamill, CPA - Senior Vice President and CFO
John joined Aprea in January 2023 from Windtree Therapeutics where he served as Senior Vice President and Chief Financial Officer since 2020. He brings more than 30 years of financial leadership experience in the pharmaceutical, biopharmaceutical, and clinical research sectors. He brings broad-based experience in financial, administrative, information technology, and facility functions, in addition to successfully completing IPO and follow-on offerings for several pharmaceutical companies. John has also recently provided consulting services to various life science companies, headed up finance at Trevena, Inc., where he was instrumental in successfully raising equity; NephroGenex, Inc., where he actively led the IPO and subsequent financial restructuring and sale of the company; Savient Pharmaceuticals, where he led a sale process resulting in $120 million in proceeds; and PharmaNet where he successfully completed its sale for approximately $250 million, which then became known as PharmaNet Development Group, where he directed financial and administrative operations for the company. John received a B.S. in Accounting and Business and Computer Science from DeSales University and is a certified public accountant.
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