Avalon GloboCare Corp., a leading global developer of innovative cell-based technologies and therapeutics and laboratory testing provider, announced that the United States Patent and Trademark Office has issued U.S. Patent No. 11,555,060, titled “QTY Fc Fusion Water Soluble Receptor Proteins”.
The “QTY Code”, is a breakthrough technology that can turn difficult to work with water-insoluble transmembrane receptor proteins into water-soluble proteins, greatly enhancing the solubility of designer peptides and proteins, therefore expanding the arsenal of selected therapeutic targets against cancers and other diseases. The patent was jointly filed with Dr. Shuguang Zhang of the Massachusetts Institute of Technology (MIT). This is one of 16 jointly filed patent applications with key strategic partners.
The next small float biotech locked and loaded!
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Day to Week: $3.46 (+10%)
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1 to 2 Weeks: $4.29 (+30%)
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Avalon GloboCare Corp. (Nasdaq: ALBT) is a clinical-stage, vertically integrated, leading CellTech bio-developer dedicated to advancing and empowering innovative, transformative immune effector cell therapy, exosome technology, as well as cell therapy related companion diagnostics.
Avalon also provides strategic advisory and outsourcing services to facilitate and enhance its clients’ growth and development, as well as competitiveness in healthcare and CellTech industry markets.
Through its subsidiary structure with unique integration of verticals from innovative R&D to automated bioproduction and accelerated clinical development, Avalon is establishing a leading role in the fields of cellular immunotherapy (including CAR-T/NK), exosome technology (ACTEX™), and regenerative therapeutics.
Avalon GloboCare Corp. (NASDAQ:ALBT) Is Headquartered In One Of The Country’s Hottest Breeding Grounds For Successful Biotechs
Avalon GloboCare Corp. (Nasdaq: ALBT) is headquartered in Freehold, New Jersey.
New Jersey’s biotechnology cluster has grown from a mere 30 companies in the early 1990s to approximately 3,200 establishments in the state today, with 46 of those firms responsible for a staggering 70 new FDA drug approvals between 2020 and 2021, according to the trade association BioNJ.
And several sources indicate that despite recent IPO and capital market challenges, the biotech cluster’s ascension continues.
Debbie Hart, president and CEO of BioNJ, says of the overall US/global biotech community: “The science is advancing by leaps and bounds, and it’s creating lots of opportunities, new companies, and new advances in therapies and treatments.”
“When you look at what happened during the global pandemic – how the industry can really save the world – [it’s] not an understatement. It just speaks to ability and the science.”
New Jersey’s specific biotech juggernaut partly stems from a constellation of cutting-edge advances in cell and gene therapy operating in tandem with a Garden State life sciences ecosystem replete with contract manufacturing and clinical research organizations, as well as specialized accountants, attorneys and other professionals who serve the industry.
Such a network is particularly important for the biotechnology community given the challenges it faces.
Dean J. Paranicas, president and CEO of the HealthCare Institute of New Jersey (HINJ), details the overall “high risk profile” for the biopharmaceutical industry: “There’s that challenge of having enough capital to develop your product, being able to get it through the regulatory cycle, and then commercializing [it] and getting it into the marketplace.”
Paranicas additionally explains that New Jersey firms have beneficial opportunities to coordinate with the state’s research institutions as well as with more established companies located here.
Also helping to lubricate the state’s growing industry is New Jersey’s proximity to Wall Street and, separately, a time-zone advantage, which facilitates business communication with locales as diverse as, say, California and the United Kingdom.
“We continue to strengthen our IP portfolio as we believe our novel QTY code protein design technology holds great potential for biotechnology applications and could generate significant clinical advancements in cellular immunotherapy and immune-oncology,”
“Our AI-enhanced protein design QTY Code technology co-developed with MIT’s Dr. Zhang is a novel platform that produces water-soluble proteins for a wide spectrum of biomedical applications including the design and construction of novel targets for application in cellular immunotherapy.”
“We are also pleased to submit a new patent application to the USPTO related to QTY glucose transporters, which are important cancer therapy targets. We believe using the QTY technology will accelerate our understanding of these proteins and the development of antibodies against them to treat cancer”
Avalon GloboCare Corp. (Nasdaq: ALBT) recently announced that it has deployed a breakthrough fusion gene map technology to be used for the goal of developing companion diagnostic kits and devices to enhance personalized clinical management of leukemia patients.
In collaboration with the Lu Daopei Institute of Hematology, a fusion gene map database from over 1,000 patients with leukemia was established and the results were previously published in the Blood Cancer Journal. Fusion genes are important genetic abnormalities in leukemia. Using advanced gene sequencing technology, called “Whole Transcriptome Sequencing” (WTS), multiple previously unknown fusion genes were identified which may potentially establish novel diagnostic and therapeutic targets.
“Fusion genes are crucial in the diagnosis and treatment of leukemia. All well-known fusion genes are founder variations and constitute critical causative factors and can serve as important indicators of disease diagnosis,” stated David Jin, M.D., Ph.D., President and Chief Executive Officer of Avalon GloboCare.
“Avalon is applying the bioinformatics from the fusion gene map with the goal of accelerating the development and commercialization of companion diagnostic kits and devices to enhance personalized clinical management of leukemia patients. The first diagnostic prototype is expected to enter clinical study and regulatory filing stage during Q3 of 2023. The fusion gene map technology also provides an unprecedented opportunity to identify and validate fusion gene products as potential novel therapeutic targets. Additionally, this gives us an opportunity to expand Avalon’s R&D pipeline and intellectual property portfolio.”
The global leukemia therapeutics market is expected to grow from $13.88 billion in 2021 to $15.27 billion in 2022 at a compound annual growth rate (CAGR) of 10.07%. The leukemia therapeutics market is expected to reach $20.77 billion in 2026 at a CAGR of 7.99%.
The leukemia therapeutics market consists of sales of the leukemia therapeutics by entities that are used for the treatment of leukemia. Leukemia is a type of blood cancer that starts in the bone marrow and proceeds to uncontrolled blood cell growth. The type treatment for leukemia depends on various factors such as age, overall health, type of leukemia, its current condition within the body and others.
The main treatment types in leukemia therapeutics are chemotherapy, immunotherapy, targeted therapy, and other treatments. Immunotherapy is a method of leukemia treatment that stimulates the body’s immune system to recognize and eliminate malignant cells.
These are used to treat acute lymphocytic leukemia, acute myeloid leukemia, chronic lymphocytic leukemia, chronic myeloid leukemia, and other type of leukemia using small molecules and biologics. The various end users of leukemia therapeutics are hospitals, homecare, specialty clinics, and other end-users.(42)
North America was the largest region in the leukemia therapeutics market in 2021. Asia Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the leukemia therapeutics market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.
IN SECTOR CONTEXT
This industry is expected to grow from $4 Billion per year in sales to over $45 Billion, a CAGR of 63%, in comparison to conventional drug sales are forecasted to have a CAGR of 6% through 2026, and biologic sales excluding cell and gene therapies are expected to have a CAGR of 5%.
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